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Bisphosphonates are medications used to treat a wide array of diseases affecting bone, including osteoporosis, multiple myeloma, and metastatic cancer. These agents reduce bone resorption and decrease the risk of bone fracture in susceptible patients. Bisphosphonates are available in both oral and intravenous (IV) formulations and have been implicated in causing osteonecrosis of the jaws. This phenomenon has been reported to occur spontaneously and more frequently, after dental extractions and/or dental surgery. Bisphosphonate-induced osteonecrosis (BON) has become a significant concern in dentistry. This course will highlight the molecular, diagnostic, and management issues of BON in the dental setting. This course is geared toward general dentists, dental specialists, and dental hygienists.